Is diabetes mellitus-linked amino acid signature associated with β-blocker-induced impaired fasting glucose?

ABSTRACT:

Background

The 5-amino acid (AA) signature, including isoleucine, leucine, valine, tyrosine, and phenylalanine, has been associated with incident diabetes mellitus and insulin resistance. We investigated whether this same AA signature, single-nucleotide polymorphisms in genes in their catabolic pathway, was associated with development of impaired fasting glucose (IFG) after atenolol treatment.

Methods and results

Among 234 European American participants enrolled in the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) study and treated with atenolol for 9 weeks, we prospectively followed a nested cohort that had both metabolomics profiling and genotype data available for the development of IFG. We assessed the association between baseline circulating levels of

SUBMITTER: Cooper-Dehoff RM 

PROVIDER: S-EPMC4050976 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature