Ontology highlight
ABSTRACT:
SUBMITTER: Dolfi DV
PROVIDER: S-EPMC4051188 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Dolfi Douglas V DV Mansfield Kathleen D KD Polley Antonio M AM Doyle Susan A SA Freeman Gordon J GJ Pircher Hanspeter H Schmader Kenneth E KE Wherry E John EJ
Journal of leukocyte biology 20130225 6
Aged individuals have increased morbidity and mortality following influenza and other viral infections, despite previous exposure or vaccination. Mouse and human studies suggest increased senescence and/or exhaustion of influenza virus-specific CD8 T cells with advanced age. However, neither the relationship between senescence and exhaustion nor the underlying transcriptional pathways leading to decreased function of influenza virus-specific cellular immunity in elderly humans are well-defined. ...[more]