A simple strategy for glycosyltransferase-catalyzed aminosugar nucleotide synthesis.

ABSTRACT: A set of 2-chloro-4-nitrophenyl glucosamino-/xylosaminosides were synthesized and assessed as potential substrates in the context of glycosyltransferase-catalyzed formation of the corresponding UDP/TDP-α-D-glucosamino-/xylosaminosugars and in single-vessel model transglycosylation reactions. This study highlights a robust platform for aminosugar nucleotide synthesis and reveals OleD Loki to be a proficient catalyst for U/TDP-aminosugar synthesis and utilization

SUBMITTER: Zhang J 

PROVIDER: S-EPMC4051237 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature