Early stress evokes age-dependent biphasic changes in hippocampal neurogenesis, BDNF expression, and cognition.

ABSTRACT:

Background

Adult-onset stressors exert opposing effects on hippocampal neurogenesis and cognition, with enhancement observed following mild stress and dysfunction following severe chronic stress. While early life stress evokes persistent changes in anxiety, it is unknown whether early stress differentially regulates hippocampal neurogenesis, trophic factor expression, and cognition across the life span.

Methods

Hippocampal-dependent cognitive behavior, neurogenesis, and epigenetic regulation of brain-derived neurotrophic factor (Bdnf) expression was examined at distinct time points across the life span in rats subjected to the early stress of maternal separation (ES) and control groups. We also examined the influence of chronic antidepressant treatment on the neurogenic, neu

SUBMITTER: Suri D 

PROVIDER: S-EPMC4051354 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature