Association between melanocytic nevi and risk of breast diseases: The French E3N prospective cohort.

ABSTRACT:

Background

While melanocytic nevi have been associated with genetic factors and childhood sun exposure, several observations also suggest a potential hormonal influence on nevi. To test the hypothesis that nevi are associated with breast tumor risk, we explored the relationships between number of nevi and benign and malignant breast disease risk.

Methods and findings

We prospectively analyzed data from E3N, a cohort of French women aged 40-65 y at inclusion in 1990. Number of nevi was collected at inclusion. Hazard ratios (HRs) for breast cancer and 95% confidence intervals (CIs) were calculated using Cox proportional hazards regression models. Associations of number of nevi with personal history of benign breast disease (BBD) and family history of breast cancer were estimat

SUBMITTER: Kvaskoff M 

PROVIDER: S-EPMC4051602 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature