Caffeine interaction with glutamate receptor gene GRIN2A: Parkinson's disease in Swedish population.

ABSTRACT: A complex interplay between genetic and environmental factors is thought to be involved in the etiology of Parkinson's disease (PD). A recent genome-wide association and interaction study (GWAIS) identified GRIN2A, which encodes an NMDA-glutamate-receptor subunit involved in brain's excitatory neurotransmission, as a PD genetic modifier in inverse association with caffeine intake. Here in, we attempted to replicate the reported association of a single nucleotide polymorphism, GRIN2A_rs4998386, and its interaction with caffeine intake with PD in patient-control study in an ethnically homogenous population in southeastern Sweden, as consistent and independent genetic association studies are the gold standard for the validation of genome-wide association studies. All the subjects (193 sporadi

SUBMITTER: Yamada-Fowler N 

PROVIDER: S-EPMC4051678 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature