Surface modifications of silica nanoparticles are crucial for their inert versus proinflammatory and immunomodulatory properties.

ABSTRACT:

Background

Silica (SiO₂) nanoparticles (NPs) are widely used in diverse industrial and biomedical applications. Their applicability depends on surface modifications, which can limit potential health problems.

Objective

To assess the potential impact of SiO₂ NP exposure and NPs chemical modifications in allergic airway inflammation.

Methods

Mice were sensitized by five repetitive intraperitoneal injections of ovalbumin/aluminum hydroxide (1 μg) over 42 days, then intratracheally instilled with plain or modified SiO₂ NPs (50 μg/mouse), and subsequently aerosol challenged for 20 minutes with ovalbumin. One or 5 days later, allergic inflammation was evaluated by cell differentiation of bronchoalveolar lavage fluid, lung function and gene expression and histopathology, as

SUBMITTER: Marzaioli V 

PROVIDER: S-EPMC4051720 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature