Reduced inflammatory phenotype in microglia derived from neonatal rat spinal cord versus brain.

ABSTRACT: Microglia are the primary immune cells of the central nervous system (CNS). Membrane bound sensors on their processes monitor the extracellular environment and respond to perturbations of the CNS such as injury or infection. Once activated, microglia play a crucial role in determining neuronal survival. Recent studies suggest that microglial functional response properties vary across different regions of the CNS. However, the activation profiles of microglia derived from the spinal cord have not been evaluated against brain microglia in vitro. Here, we studied the morphological properties and secretion of inflammatory and trophic effectors by microglia derived from the brain or spinal cord of neonatal rats under basal culture conditions and after activation with lipopolysaccharide (LPS). O

SUBMITTER: Baskar Jesudasan SJ 

PROVIDER: S-EPMC4051776 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature