Cross-sectional and longitudinal relationships between cerebrospinal fluid biomarkers and cognitive function in people without cognitive impairment from across the adult life span.

ABSTRACT:

Importance

Age-related cognitive decline among older individuals with normal cognition is a complex trait that potentially derives from processes of aging, inherited vulnerabilities, environmental factors, and common latent diseases that can progress to cause dementia, such as Alzheimer disease and vascular brain injury.

Objective

To use cerebrospinal fluid (CSF) biomarkers to gain insight into this complex trait.

Design, setting, and participants

Secondary analyses of an academic multicenter cross-sectional (n = 315) and longitudinal (n = 158) study of 5 neuropsychological tests (Immediate Recall, Delayed Recall, Trail Making Test Parts A and B, and Category Fluency) in cognitively normal individuals aged 21 to 100 years.

Main outcomes and measures

To investig

SUBMITTER: Li G 

PROVIDER: S-EPMC4051849 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature