Gene expression profile in delay graft function: inflammatory markers are associated with recipient and donor risk factors.

ABSTRACT:

Background

Delayed graft function (DGF) remains an important problem after kidney transplantation and reduced long-term graft survival of the transplanted organ. The aim of the present study was to determine if the development of DGF was associated with a specific pattern of inflammatory gene expression in expanded criteria of deceased donor kidney transplantation. Also, we explored the presence of correlations between DGF risk factors and the profile that was found.

Methods

Seven days after kidney transplant, a cDNA microarray was performed on biopsies of graft from patients with and without DGF. Data was confirmed by real-time PCR. Correlations were performed between inflammatory gene expression and clinical risk factors.

Results

From a total of 84 genes analyzed, 5

SUBMITTER: Guerrieri D 

PROVIDER: S-EPMC4052172 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature