Global gene expression profiling of proliferative phase endometrium reveals distinct functional subdivisions.

ABSTRACT: The human endometrium follows a predictable pattern of development during the proliferative phase. Endometrial thickness increases after day 3 and then plateaus at days 9 to 10 of the menstrual cycle despite continued high serum levels of estrogen. We hypothesized that proliferative phase endometrium undergoes more than simple estrogen responsive growth, rather it is characterized by complex time-dependent functional activities reflected in differential gene expression. Nine endometrial RNA samples from healthy participants were subjected to microarray analysis and 15 samples were used for quantitative real-time polymerase chain reaction. The samples were divided into early, mid, or late proliferative phase. The early proliferative phase showed higher expression of genes including transfor

SUBMITTER: Petracco RG 

PROVIDER: S-EPMC4052207 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature