Investigating perturbed pathway modules from gene expression data via structural equation models.

ABSTRACT:

Background

It is currently accepted that the perturbation of complex intracellular networks, rather than the dysregulation of a single gene, is the basis for phenotypical diversity. High-throughput gene expression data allow to investigate changes in gene expression profiles among different conditions. Recently, many efforts have been made to individuate which biological pathways are perturbed, given a list of differentially expressed genes (DEGs). In order to understand these mechanisms, it is necessary to unveil the variation of genes in relation to each other, considering the different phenotypes. In this paper, we illustrate a pipeline, based on Structural Equation Modeling (SEM) that allowed to investigate pathway modules, considering not only deregulated genes but also the co

SUBMITTER: Pepe D 

PROVIDER: S-EPMC4052286 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature