High-density lipoprotein particle subclass heterogeneity and incident coronary heart disease.

ABSTRACT:

Background

Raising the cholesterol of high-density lipoprotein (HDL) particles is targeted as a cardiovascular disease prevention strategy. However, HDL particles are heterogeneous in composition and structure, which may relate to differences in antiatherogenic potential. We prospectively evaluated the association of HDL subclasses, defined by a recently proposed nomenclature, with incident coronary heart disease (CHD).

Methods and results

Baseline HDL particle concentrations were measured by nuclear magnetic resonance spectroscopy and categorized into 5 subclasses (very large, large, medium, small, and very small) among 26 332 initially healthy women. During a median follow-up of 17 years, 969 cases of incident CHD (myocardial infarction, revascularization, and CHD death) w

SUBMITTER: Akinkuolie AO 

PROVIDER: S-EPMC4052434 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature