Epidemiological risk factors associated with high global frequency of inapparent dengue virus infections.

ABSTRACT: Dengue is a major international public health concern, and the number of outbreaks has escalated greatly. Human migration and international trade and travel are constantly introducing new vectors and pathogens into novel geographic areas. Of particular interest is the extent to which dengue virus (DENV) infections are subclinical or inapparent. Not only may such infections contribute to the global spread of DENV by human migration, but also seroprevalence rates in naïve populations may be initially high despite minimal numbers of detectable clinical cases. As the probability of severe disease is increased in secondary infections, populations may thus be primed, with serious public health consequences following introduction of a new serotype. In addition, pre-existing immunity from inappare

SUBMITTER: Grange L 

PROVIDER: S-EPMC4052743 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature