Breast cancer prognosis risk estimation using integrated gene expression and clinical data.

ABSTRACT:

Background

Novel prognostic markers are needed so newly diagnosed breast cancer patients do not undergo any unnecessary therapy. Various microarray gene expression datasets based studies have generated gene signatures to predict the prognosis outcomes, while ignoring the large amount of information contained in established clinical markers. Nevertheless, small sample sizes in individual microarray datasets remain a bottleneck in generating robust gene signatures that show limited predictive power. The aim of this study is to achieve high classification accuracy for the good prognosis group and then achieve high classification accuracy for the poor prognosis group.

Methods

We propose a novel algorithm called the IPRE (integrated prognosis risk estimation) algorithm. We used i

SUBMITTER: Saini A 

PROVIDER: S-EPMC4052785 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature