ASMT gene expression correlates with cognitive impairment in patients with recurrent depressive disorder.

ABSTRACT:

Background

Recurrent depressive disorder is a multifactorial disease; one of the typical features is cognitive impairment. The purpose of this study was analysis of ASMT gene expression both on mRNA and protein levels in patients with recurrent depressive disorder (rDD) and assessment of the relationship between plasma level of ASMT protein, gene expression on mRNA level, and cognitive performance.

Material and methods

The study included 236 subjects: patients with rDD (n=131) and healthy subjects (n=105, CG). Cognitive function assessment was based on: Trail Making Test, The Stroop Test, Verbal Fluency Test (VFT), and Auditory Verbal Learning Test (AVLT).

Results

Both mRNA and protein expression levels of ASMT gene were significantly higher in healthy subjects when c

SUBMITTER: Talarowska M 

PROVIDER: S-EPMC4052942 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature