Low levels of Stat5a protein in breast cancer are associated with tumor progression and unfavorable clinical outcomes.

ABSTRACT:

Introduction

Signal transducer and activator of transcripton-5a (Stat5a) and its close homologue, Stat5b, mediate key physiological effects of prolactin and growth hormone in mammary glands. In breast cancer, loss of nuclear localized and tyrosine phosphorylated Stat5a/b is associated with poor prognosis and increased risk of antiestrogen therapy failure. Here we quantify for the first time levels of Stat5a and Stat5b over breast cancer progression, and explore their potential association with clinical outcome.

Methods

Stat5a and Stat5b protein levels were quantified in situ in breast-cancer progression material. Stat5a and Stat5b transcript levels in breast cancer were correlated with clinical outcome in 936 patients. Stat5a protein was further quantified in four archival c

SUBMITTER: Peck AR 

PROVIDER: S-EPMC4053108 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature