P130Cas/Cyclooxygenase-2 axis in the control of mesenchymal plasticity of breast cancer cells.

ABSTRACT:

Introduction

Intrinsic plasticity of breast carcinoma cells allows them to undergo a transient and reversible conversion into mesenchymal cells to disseminate into distant organs, where they can re-differentiate to an epithelial-like status to form a cohesive secondary mass. The p130Cas scaffold protein is overexpressed in human ER+ and HER2+ breast cancer where it contributes to cancer progression, invasion and resistance to therapy. However, its role in regulating mesenchymal aggressive breast cancer cells remains to be determined. The aim of this study was to investigate the molecular and functional involvement of this adaptor protein in breast cancer cell plasticity.

Methods

We used silencing strategies and rescue experiments to evaluate phenotypic and biochemical change

SUBMITTER: Bisaro B 

PROVIDER: S-EPMC4053116 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature