SIRT1 pathway dysregulation in the smoke-exposed airway epithelium and lung tumor tissue.

ABSTRACT: Cigarette smoke produces a molecular field of injury in epithelial cells lining the respiratory tract. However, the specific signaling pathways that are altered in the airway of smokers and the signaling processes responsible for the transition from smoking-induced airway damage to lung cancer remain unknown. In this study, we use a genomic approach to study the signaling processes associated with tobacco smoke exposure and lung cancer. First, we developed and validated pathway-specific gene expression signatures in bronchial airway epithelium that reflect activation of signaling pathways relevant to tobacco exposure, including ATM, BCL2, GPX1, NOS2, IKBKB, and SIRT1. Using these profiles and four independent gene expression datasets, we found that SIRT1 activity is significantly upregulat

SUBMITTER: Beane J 

PROVIDER: S-EPMC4053174 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature