Liver × receptor ligands disrupt breast cancer cell proliferation through an E2F-mediated mechanism.

ABSTRACT:

Introduction

Liver × receptors (LXRs) are members of the nuclear receptor family of ligand-dependent transcription factors and have established functions as regulators of cholesterol, glucose, and fatty acid metabolism and inflammatory responses. Published reports of anti-proliferative effects of synthetic LXR ligands on breast, prostate, ovarian, lung, skin, and colorectal cancer cells suggest that LXRs are potential targets in cancer prevention and treatment.

Methods

To further determine the effects of LXR ligands and identify their potential mechanisms of action in breast cancer cells, we carried out microarray analysis of gene expression in four breast cancer cell lines following treatments with the synthetic LXR ligand GW3965. Differentially expressed genes were further

SUBMITTER: Nguyen-Vu T 

PROVIDER: S-EPMC4053202 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature