Integrated pathway clusters with coherent biological themes for target prioritisation.

ABSTRACT: Prioritising candidate genes for further experimental characterisation is an essential, yet challenging task in biomedical research. One way of achieving this goal is to identify specific biological themes that are enriched within the gene set of interest to obtain insights into the biological phenomena under study. Biological pathway data have been particularly useful in identifying functional associations of genes and/or gene sets. However, biological pathway information as compiled in varied repositories often differs in scope and content, preventing a more effective and comprehensive characterisation of gene sets. Here we describe a new approach to constructing biologically coherent gene sets from pathway data in major public repositories and employing them for functional analysis of l

SUBMITTER: Chen YA 

PROVIDER: S-EPMC4053319 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature