The human antibody response to the surface of Mycobacterium tuberculosis.

ABSTRACT:

Background

Vaccine-induced human antibodies to surface components of Haemophilus influenzae and Streptococcus pneumonia are correlated with protection. Monoclonal antibodies to surface components of Mycobacterium tuberculosis are also protective in animal models. We have characterized human antibodies that bind to the surface of live M. tuberculosis.

Methods

Plasma from humans with latent tuberculosis (TB) infection (n = 23), active TB disease (n = 40), and uninfected controls (n = 9) were assayed by ELISA for reactivity to the live M. tuberculosis surface and to inactivated M. tuberculosis fractions (whole cell lysate, lipoarabinomannan, cell wall, and secreted proteins).

Results

When compared to uninfected controls, patients with active TB disease had higher antibod

SUBMITTER: Perley CC 

PROVIDER: S-EPMC4053328 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature