DNA hypermethylation and DNA hypomethylation is present at different loci in chronic kidney disease.

ABSTRACT: Genetic risk factors for chronic kidney disease (CKD) are being identified through international collaborations. By comparison, epigenetic risk factors for CKD have only recently been considered using population-based approaches. DNA methylation is a major epigenetic modification that is associated with complex diseases, so we investigated methylome-wide loci for association with CKD. A total of 485,577 unique features were evaluated in 255 individuals with CKD (cases) and 152 individuals without evidence of renal disease (controls). Following stringent quality control, raw data were quantile normalized and β values calculated to reflect the methylation status at each site. The difference in methylation status was evaluated between cases and controls with resultant P values adjusted for mu

SUBMITTER: Smyth LJ 

PROVIDER: S-EPMC4053455 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature