Whole blood cells loaded with messenger RNA as an anti-tumor vaccine.

ABSTRACT: The use of a cell-based vaccine composed of autologous whole blood cells loaded with mRNA is described. Mice immunized with whole blood cells loaded with mRNA encoding antigen develop anti-tumor immunity comparable to DC-RNA immunization. This approach offers a simple and affordable alternative to RNA-based cellular therapy by circumventing complex, laborious and expensive ex vivo manipulations required for DC-based immunizations.

SUBMITTER: Phua KK 

PROVIDER: S-EPMC4053491 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature