Relationship between apparent diffusion coefficient and tumour cellularity in lung cancer.

ABSTRACT:

Background and objective

To prospectively investigate the relationship between the apparent diffusion coefficient (ADC) and cellularity in lung cancer.

Methods

Sixty patients histopathologically confirmed with lung cancer (41 men, 19 women) underwent diffusion-weighted magnetic resonance imaging of the chest (with b values of 50 and 1000 s/mm2). The median mean ADC (ADC mean) value and median minimum ADC (ADC min) value within each primary tumour were calculated and compared with the median nucleo-cytoplasmic ratio (NCR), which was selected to represent the cellularity. The correlation between the NCR and ADC mean/ADC min was calculated with SPSS 18.0 software.

Results

The mean ADC mean values, ADC min values and median NCR were (1.07 ± 0.12) × 10(-3) mm2/s, (0.86 ± 0

SUBMITTER: Chen L 

PROVIDER: S-EPMC4053522 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature