External validation of a prognostic model for seizure recurrence following a first unprovoked seizure and implications for driving.

ABSTRACT:

Objective

In the United Kingdom and other European Union countries guidelines for driving following a first unprovoked seizure require the risk of another seizure in the next year to be less than 20%. Using data from one clinical trial, we previously developed a prognostic model to inform driving guidelines. The objective of this work is to externally validate our published model and demonstrate its generalisability.

Methods

A cohort of 620 people with a first unprovoked seizure was used to develop the original model which included variables for aetiology, first degree relative with epilepsy, seizures only while asleep, electroencephalogram, computed tomography or magnetic resonance scan result, and treatment policy. The validation cohorts consisted of 274 (United Kingdom),

SUBMITTER: Bonnett LJ 

PROVIDER: S-EPMC4053525 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature