Hypothalamic food intake regulation in a cancer-cachectic mouse model.

ABSTRACT:

Background

Appetite is frequently affected in cancer patients leading to anorexia and consequently insufficient food intake. In this study, we report on hypothalamic gene expression profile of a cancer-cachectic mouse model with increased food intake. In this model, mice bearing C26 tumour have an increased food intake subsequently to the loss of body weight. We hypothesise that in this model, appetite-regulating systems in the hypothalamus, which apparently fail in anorexia, are still able to adapt adequately to changes in energy balance. Therefore, studying changes that occur on appetite regulators in the hypothalamus might reveal targets for treatment of cancer-induced eating disorders. By applying transcriptomics, many appetite-regulating systems in the hypothalamus could be ta

SUBMITTER: Dwarkasing JT 

PROVIDER: S-EPMC4053566 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature