Age independently affects myelin integrity as detected by magnetization transfer magnetic resonance imaging in multiple sclerosis.

ABSTRACT:

Background

Multiple sclerosis (MS) is a heterogeneous disorder with a progressive course that is difficult to predict on a case-by-case basis. Natural history studies of MS have demonstrated that age influences clinical progression independent of disease duration.

Objective

To determine whether age would be associated with greater CNS injury as detected by magnetization transfer MRI.

Materials and methods

Forty MS patients were recruited from out-patient clinics into two groups stratified by age but with similar clinical disease duration as well as thirteen controls age-matched to the older MS group. Images were segmented by automated programs and blinded readers into normal appearing white matter (NAWM), normal appearing gray matter (NAGM), and white matter lesions (

SUBMITTER: Newbould RD 

PROVIDER: S-EPMC4053639 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature