The genome and developmental transcriptome of the strongylid nematode Haemonchus contortus.

ABSTRACT:

Background

The barber's pole worm, Haemonchus contortus, is one of the most economically important parasites of small ruminants worldwide. Although this parasite can be controlled using anthelmintic drugs, resistance against most drugs in common use has become a widespread problem. We provide a draft of the genome and the transcriptomes of all key developmental stages of H. contortus to support biological and biotechnological research areas of this and related parasites.

Results

The draft genome of H. contortus is 320 Mb in size and encodes 23,610 protein-coding genes. On a fundamental level, we elucidate transcriptional alterations taking place throughout the life cycle, characterize the parasite's gene silencing machinery, and explore molecules involved in development, rep

SUBMITTER: Schwarz EM 

PROVIDER: S-EPMC4053716 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature