Differential DNA methylation in discrete developmental stages of the parasitic nematode Trichinella spiralis.

ABSTRACT:

Background

DNA methylation plays an essential role in regulating gene expression under a variety of conditions and it has therefore been hypothesized to underlie the transitions between life cycle stages in parasitic nematodes. So far, however, 5'-cytosine methylation has not been detected during any developmental stage of the nematode Caenorhabditis elegans. Given the new availability of high-resolution methylation detection methods, an investigation of life cycle methylation in a parasitic nematode can now be carried out.

Results

Here, using MethylC-seq, we present the first study to confirm the existence of DNA methylation in the parasitic nematode Trichinella spiralis, and we characterize the methylomes of the three life-cycle stages of this food-borne infectious human p

SUBMITTER: Gao F 

PROVIDER: S-EPMC4053732 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature