Aging effects on DNA methylation modules in human brain and blood tissue.

ABSTRACT:

Background

Several recent studies reported aging effects on DNA methylation levels of individual CpG dinucleotides. But it is not yet known whether aging-related consensus modules, in the form of clusters of correlated CpG markers, can be found that are present in multiple human tissues. Such a module could facilitate the understanding of aging effects on multiple tissues.

Results

We therefore employed weighted correlation network analysis of 2,442 Illumina DNA methylation arrays from brain and blood tissues, which enabled the identification of an age-related co-methylation module. Module preservation analysis confirmed that this module can also be found in diverse independent data sets. Biological evaluation showed that module membership is associated with Polycomb group ta

SUBMITTER: Horvath S 

PROVIDER: S-EPMC4053733 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature