Transcriptional profiling of long non-coding RNAs and novel transcribed regions across a diverse panel of archived human cancers.

ABSTRACT:

Background

Molecular characterization of tumors has been critical for identifying important genes in cancer biology and for improving tumor classification and diagnosis. Long non-coding RNAs, as a new, relatively unstudied class of transcripts, provide a rich opportunity to identify both functional drivers and cancer-type-specific biomarkers. However, despite the potential importance of long non-coding RNAs to the cancer field, no comprehensive survey of long non-coding RNA expression across various cancers has been reported.

Results

We performed a sequencing-based transcriptional survey of both known long non-coding RNAs and novel intergenic transcripts across a panel of 64 archival tumor samples comprising 17 diagnostic subtypes of adenocarcinomas, squamous cell carcinomas

SUBMITTER: Brunner AL 

PROVIDER: S-EPMC4053743 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature