Cytosine methylation changes in enhancer regions of core pro-fibrotic genes characterize kidney fibrosis development.

ABSTRACT:

Background

One in eleven people is affected by chronic kidney disease, a condition characterized by kidney fibrosis and progressive loss of kidney function. Epidemiological studies indicate that adverse intrauterine and postnatal environments have a long-lasting role in chronic kidney disease development. Epigenetic information represents a plausible carrier for mediating this programming effect. Here we demonstrate that genome-wide cytosine methylation patterns of healthy and chronic kidney disease tubule samples obtained from patients show significant differences.

Results

We identify differentially methylated regions and validate these in a large replication dataset. The differentially methylated regions are rarely observed on promoters, but mostly overlap with putative en

SUBMITTER: Ko YA 

PROVIDER: S-EPMC4053753 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature