Genome-wide analysis links emerin to neuromuscular junction activity in Caenorhabditis elegans.

ABSTRACT:

Background

Laminopathies are diseases characterized by defects in nuclear envelope structure. A well-known example is Emery-Dreifuss muscular dystrophy, which is caused by mutations in the human lamin A/C and emerin genes. While most nuclear envelope proteins are ubiquitously expressed, laminopathies often affect only a subset of tissues. The molecular mechanisms underlying these tissue-specific manifestations remain elusive. We hypothesize that different functional subclasses of genes might be differentially affected by defects in specific nuclear envelope components.

Results

Here we determine genome-wide DNA association profiles of two nuclear envelope components, lamin/LMN-1 and emerin/EMR-1 in adult Caenorhabditis elegans. Although both proteins bind to transcriptionally

SUBMITTER: Gonzalez-Aguilera C 

PROVIDER: S-EPMC4053756 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature