P53 induces transcriptional and translational programs to suppress cell proliferation and growth.

ABSTRACT:

Background

Cell growth and proliferation are tightly connected to ensure that appropriately sized daughter cells are generated following mitosis. Energy stress blocks cell growth and proliferation, a critical response for survival under extreme conditions. Excessive oncogenic stress leads to p53 activation and the induction of senescence, an irreversible state of cell-cycle arrest and a critical component in the suppression of tumorigenesis. Nutrient-sensing and mitogenic cues converge on a major signaling node, which regulates the activity of the mTOR kinase. Although transcriptional responses to energy and oncogenic stresses have been examined by many gene-expression experiments, a global exploration of the modulation of mRNA translation in response to these conditions is lacking

SUBMITTER: Loayza-Puch F 

PROVIDER: S-EPMC4053767 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature