Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes.

ABSTRACT:

Background

DNA methylation and the Polycomb repression system are epigenetic mechanisms that play important roles in maintaining transcriptional repression. Recent evidence suggests that DNA methylation can attenuate the binding of Polycomb protein components to chromatin and thus plays a role in determining their genomic targeting. However, whether this role of DNA methylation is important in the context of transcriptional regulation is unclear.

Results

By genome-wide mapping of the Polycomb Repressive Complex 2-signature histone mark, H3K27me3, in severely DNA hypomethylated mouse somatic cells, we show that hypomethylation leads to widespread H3K27me3 redistribution, in a manner that reflects the local DNA methylation status in wild-type cells. Unexpectedly, we observe st

SUBMITTER: Reddington JP 

PROVIDER: S-EPMC4053768 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature