Pint lincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2.

ABSTRACT:

Background

The p53 transcription factor is located at the core of a complex wiring of signaling pathways that are critical for the preservation of cellular homeostasis. Only recently it has become clear that p53 regulates the expression of several long intergenic noncoding RNAs (lincRNAs). However, relatively little is known about the role that lincRNAs play in this pathway.

Results

Here we characterize a lincRNA named Pint (p53 induced noncoding transcript). We show that Pint is aubiquitously expressed lincRNA that is finely regulated by p53. In mouse cells, Pint promotes cell proliferation and survival by regulating the expression of genes of the TGF-b, MAPK and p53 pathways. Pint is a nuclear lincRNA that directly interacts with the Polycomb repressive complex 2 (PRC2), a

SUBMITTER: Marin-Bejar O 

PROVIDER: S-EPMC4053822 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature