Mammalian conserved ADAR targets comprise only a small fragment of the human editosome.

ABSTRACT:

Background

ADAR proteins are among the most extensively studied RNA binding proteins. They bind to their target and deaminate specific adenosines to inosines. ADAR activity is essential, and the editing of a subset of their targets is critical for viability. Recently, a huge number of novel ADAR targets were detected by analyzing next generation sequencing data. Most of these novel editing sites are located in lineage-specific genomic repeats, probably a result of overactivity of editing enzymes, thus masking the functional sites. In this study we aim to identify the set of mammalian conserved ADAR targets.

Results

We used RNA sequencing data from human, mouse, rat, cow, opossum, and platypus to define the conserved mammalian set of ADAR targets. We found that the conserved

SUBMITTER: Pinto Y 

PROVIDER: S-EPMC4053846 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature