Inactive or moderately active human promoters are enriched for inter-individual epialleles.

ABSTRACT:

Background

Inter-individual epigenetic variation, due to genetic, environmental or random influences, is observed in many eukaryotic species. In mammals, however, the molecular nature of epiallelic variation has been poorly defined, partly due to the restricted focus on DNA methylation. Here we report the first genome-scale investigation of mammalian epialleles that integrates genomic, methylomic, transcriptomic and histone state information.

Results

First, in a small sample set, we demonstrate that non-genetically determined inter-individual differentially methylated regions (iiDMRs) can be temporally stable over at least 2 years. Then, we show that iiDMRs are associated with changes in chromatin state as measured by inter-individual differences in histone variant H2A.Z lev

SUBMITTER: Gemma C 

PROVIDER: S-EPMC4053860 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature