The coronary artery disease-associated 9p21 variant and later life 20-year survival to cohort extinction.

ABSTRACT:

Background

Common variation at chromosome 9p21 (marked by rs10757278 or rs1333049) is associated with coronary artery disease (CAD) and peripheral vascular disease. A decreasing effect at older age was suggested, and effects on long-term mortality are unclear. We estimated 9p21 associations with CAD and all-cause mortality in a CAD diagnosis-free older population. We also estimated classification gains on adding the variant to the Framingham Risk Score (FRS) for CAD.

Methods and results

DNA was from an Established Populations for Epidemiological Study of the Elderly-Iowa cohort from 1988 (participants >71 years), with death certificates obtained to 2008 for 92% of participants. Cox regression models were adjusted for confounders and CAD risk factors. Of 1095 CAD diagnosis-fr

SUBMITTER: Dutta A 

PROVIDER: S-EPMC4053863 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature