The genome and transcriptome of the enteric parasite Entamoeba invadens, a model for encystation.

ABSTRACT:

Background

Several eukaryotic parasites form cysts that transmit infection. The process is found in diverse organisms such as Toxoplasma, Giardia, and nematodes. In Entamoeba histolytica this process cannot be induced in vitro, making it difficult to study. In Entamoeba invadens, stage conversion can be induced, but its utility as a model system to study developmental biology has been limited by a lack of genomic resources. We carried out genome and transcriptome sequencing of E. invadens to identify molecular processes involved in stage conversion.

Results

We report the sequencing and assembly of the E. invadens genome and use whole transcriptome sequencing to characterize changes in gene expression during encystation and excystation. The E. invadens genome is larger than t

SUBMITTER: Ehrenkaufer GM 

PROVIDER: S-EPMC4053983 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature