The BET protein FSH functionally interacts with ASH1 to orchestrate global gene activity in Drosophila.

ABSTRACT:

Background

The question of how cells re-establish gene expression states after cell division is still poorly understood. Genetic and molecular analyses have indicated that Trithorax group (TrxG) proteins are critical for the long-term maintenance of active gene expression states in many organisms. A generally accepted model suggests that TrxG proteins contribute to maintenance of transcription by protecting genes from inappropriate Polycomb group (PcG)-mediated silencing, instead of directly promoting transcription.

Results and discussion

Here we report a physical and functional interaction in Drosophila between two members of the TrxG, the histone methyltransferase ASH1 and the bromodomain and extraterminal family protein FSH. We investigated this interface at the genome le

SUBMITTER: Kockmann T 

PROVIDER: S-EPMC4053998 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature