The mutational landscape of chromatin regulatory factors across 4,623 tumor samples.

ABSTRACT:

Background

Chromatin regulatory factors are emerging as important genes in cancer development and are regarded as interesting candidates for novel targets for cancer treatment. However, we lack a comprehensive understanding of the role of this group of genes in different cancer types.

Results

We have analyzed 4,623 tumor samples from thirteen anatomical sites to determine which chromatin regulatory factors are candidate drivers in these different sites. We identify 34 chromatin regulatory factors that are likely drivers in tumors from at least one site, all with relatively low mutational frequency. We also analyze the relative importance of mutations in this group of genes for the development of tumorigenesis in each site, and indifferent tumor types from the same site.

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SUBMITTER: Gonzalez-Perez A 

PROVIDER: S-EPMC4054018 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature