N-linked glycosylation in Archaea: a structural, functional, and genetic analysis.

ABSTRACT: N-glycosylation of proteins is one of the most prevalent posttranslational modifications in nature. Accordingly, a pathway with shared commonalities is found in all three domains of life. While excellent model systems have been developed for studying N-glycosylation in both Eukarya and Bacteria, an understanding of this process in Archaea was hampered until recently by a lack of effective molecular tools. However, within the last decade, impressive advances in the study of the archaeal version of this important pathway have been made for halophiles, methanogens, and thermoacidophiles, combining glycan structural information obtained by mass spectrometry with bioinformatic, genetic, biochemical, and enzymatic data. These studies reveal both features shared with the eukaryal and bacterial do

SUBMITTER: Jarrell KF 

PROVIDER: S-EPMC4054257 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature