Dissecting the cis and trans elements that regulate adjacent-gene coregulation in Saccharomyces cerevisiae.

ABSTRACT: The relative positions that genes occupy on their respective chromosomes can play a critical role in determining how they are regulated at the transcriptional level. For example, a significant fraction of the genes from a variety of coregulated gene sets, including the ribosomal protein (RP) and the rRNA and ribosome biogenesis (RRB) regulons, exist as immediate, adjacent gene pairs. These gene pairs occur in all possible divergent, tandem, and convergent orientations. Adjacent-gene pairing in these regulons is associated with a tighter transcriptional coregulation than is observed for nonpaired genes of the same regulons. In order to define the cis and trans factors that regulate adjacent-gene coregulation (AGC), we conducted a mutational analysis of the convergently oriented RRB gene pai

SUBMITTER: Arnone JT 

PROVIDER: S-EPMC4054278 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature