Pathogenic features associated with increased virulence upon Simian immunodeficiency virus cross-species transmission from natural hosts.

ABSTRACT:

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While simian immunodeficiency viruses (SIVs) are generally nonpathogenic in their natural hosts, dramatic increases in pathogenicity may occur upon cross-species transmission to new hosts. Deciphering the drivers of these increases in virulence is of major interest for understanding the emergence of new human immunodeficiency viruses (HIVs). We transmitted SIVsab from the sabaeus species of African green monkeys (AGMs) to pigtailed macaques (PTMs). High acute viral replication occurred in all SIVsab-infected PTMs, yet the outcome of chronic infection was highly variable, ranging from rapid progression to controlled infection, which was independent of the dynamics of acute viral replication, CD4(+) T cell depletion, or preinfection levels of microbial translocation. Infec

SUBMITTER: Mandell DT 

PROVIDER: S-EPMC4054382 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature