Live attenuated tetravalent dengue virus host range vaccine is immunogenic in African green monkeys following a single vaccination.

ABSTRACT:

Unlabelled

The causative agent of dengue fever, dengue virus (DENV), is transmitted by mosquitoes, and as distribution of these insects has expanded, so has dengue-related disease. DENV is a member of the Flaviviridae family and has 4 distinct serotypes (DENV-1, -2, -3, and -4). No lasting cross protection is afforded to heterologous serotypes following infection by any one of the individual serotypes. The presence of nonneutralizing antibodies to one serotype can facilitate the occurrence of more-severe dengue hemorrhagic fever through immune enhancement upon infection with a second serotype. For this reason, the development of a safe, tetravalent vaccine to produce a balanced immune response to all four serotypes is critical. We have developed a novel approach to produce safe and

SUBMITTER: Briggs CM 

PROVIDER: S-EPMC4054385 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature