Interspecies differences in virus uptake versus cardiac function of the coxsackievirus and adenovirus receptor.

ABSTRACT:

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The coxsackievirus and adenovirus receptor (CAR) is a cell contact protein with an important role in virus uptake. Its extracellular immunoglobulin domains mediate the binding to coxsackievirus and adenovirus as well as homophilic and heterophilic interactions between cells. The cytoplasmic tail links CAR to the cytoskeleton and intracellular signaling cascades. In the heart, CAR is crucial for embryonic development, electrophysiology, and coxsackievirus B infection. Noncardiac functions are less well understood, in part due to the lack of suitable animal models. Here, we generated a transgenic mouse that rescued the otherwise embryonic-lethal CAR knockout (KO) phenotype by expressing chicken CAR exclusively in the heart. Using this rescue model, we addressed interspecie

SUBMITTER: Freiberg F 

PROVIDER: S-EPMC4054445 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature