Induction of Gag-specific CD4 T cell responses during acute HIV infection is associated with improved viral control.

ABSTRACT:

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Effector CD4 T cell responses have been shown to be critically involved in the containment and clearance of viral pathogens. However, their involvement in the pathogenesis of HIV infection is less clear, given their additional role as preferred viral targets. We previously demonstrated that the presence of HIV-specific CD4 T cell responses is somewhat associated with HIV control and that specific CD4 T cell functions, such as direct cytolytic activity, can contribute to control of HIV viremia. However, little is known about how the induction of HIV-specific CD4 T cell responses during acute HIV infection influences disease progression and whether responses induced during the early phase of infection are preferentially depleted. We therefore longitudinally assessed, in a

SUBMITTER: Schieffer M 

PROVIDER: S-EPMC4054446 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature