Within-host evolution results in antigenically distinct GII.4 noroviruses.

ABSTRACT:

Unlabelled

Genogroup II, genotype 4 (GII.4) noroviruses are known to rapidly evolve, with the emergence of a new primary strain every 2 to 4 years as herd immunity to the previously circulating strain is overcome. Because viral genetic diversity is higher in chronic than in acute infection, chronically infected immunocompromised people have been hypothesized to be a potential source for new epidemic GII.4 strains. However, while some capsid protein residues are under positive selection and undergo patterned changes in sequence variation over time, the relationships between genetic variation and antigenic variation remains unknown. Based on previously published GII.4 strains from a chronically infected individual, we synthetically reconstructed virus-like particles (VLPs) representi

SUBMITTER: Debbink K 

PROVIDER: S-EPMC4054459 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature